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Advanced Max. Strength Formula





BIOME DEFENSE® Unique Bioactive(s) 

BIOME DEFENSE® Maximum Strength offers more diverse and
contrasting mechanisms of action that directly target pain and inflammation.

BIOME DEFENSE® is also one of the most advanced IC support formulas
NAN offers and includes support for the entire pelvis and lower lumbar region.  

Woman & Doctor
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Maximum Strength Formula

BIOME DEFENSE® is an advanced higher level formula option with its own unique set of bioactive ingredients delivered at appropriate dosages.

BIOME DEFENSE® may also support the inhibition
of TNFα, IL1β, IL6, IL8, IL10, IL17A, CRP, and NGF.
This may help decrease refractory bladder, pelvis,
and lumbar pain, including inflammation, urgency
and frequency, and may also help reduce nocturia.

BIOME DEFENSE® is designed for patients who
have experienced limited success with other 
IC support nutraceutical options. This formula is recommended for those who are looking for an alternative natural pathway to support a better quality of life in regards to IC/ BPS and LUTS (lower unitary tract symptoms), which include the bladder, pelvis and lower lumbar-back.

Please discuss with your doctor to make sure there are no contraindications with BIOME DEFENSE® in regards to your medication and or any medical condition.

BIOME DEFENSE® Ingredient Profile


Omega 3 PUFAs

BIOME DEFENSE® contains omega 3s, which are polyunsaturated fatty acids (PUFAs) that may suppress inflammation throughout the body and also offer a great benefit to IC patients and other urologic conditions. 

PEA Pamitoylethanolamide in Biome Defense to Support Pain Reduction

PEA Palmitoylethanolamide

BIOME DEFENSE® contains palmitoylethanolamide (PEA), an endocannabinoid-like lipid that has been shown to decrease bladder in pelvic pain in several clinical trials with its analgesic properties.

Oracran Cranberry Extract in Biome Defense to help mitigate E.Coli in the Urinary Tract

ORACRAN Cranberry Extract

BIOME DEFENSE® contains ORACRAN™ cranberry extract which has shown to have strong anti-adhesion activity (AAA) against E. coli within the urinary tract.

Quercetin in Biome Defense to support reduced Inflammation and Pain


BIOME DEFENSE® contains quercetin, a bioflavonoid that has potent anti-mast cell activity and anti-inflammatory properties and can help with the improvement of IC symptoms.

Boswellia Extract in Biome Defense to Support Reduced Inflammation and Pain

Boswellia Serrata Extract

BIOME DEFENSE® contains Boswellia Serrata extract which has been shown to help urothelial wound healing in relation to cystitis.

Bromelain in Biome Defense to Support Inflammtion Reduction


BIOME DEFENSE® contains bromelain, an enzyme derived from the pineapple fruit that supports anti-inflammation.

Omega 3's in Biome Defense to Support Infammation and Pain Relief

Chondroitin Sulfate

BIOME DEFENSE® contains chondroitin sulfate, which has been shown to promote the regeneration of the bladder's GAG (urothelium).

Curcumin in Biome Defense


BIOME DEFENSE® contains curcumin, a Curcuma Longa extract that may help treat the inflammation that leads to IC symptoms.

Premium Vitamins and Minerals in Biome Defense for Better Bladder Health

Select Vitamins and Minerals

BIOME DEFENSE® contains select vitamins and minerals to help calm symptoms and promote better overall immune health.

Highest Quality Standards

Third-Party Tested
2. Delayed-Release Capsule
3. Drug and Antibiotic Free
4. Made in a cGMP Organic Certified Facility
5. Gluten-Free
6. Yeast-Free
7. Non-GMO
8. Made in the USA
9. Preservative Free
10. No Artificial Flavors or Ingredients 
11. No Magnesium Stearate or Vegetable Stearate

Friends by the Lake

Health and Medical Information Disclaimer:

The information provided on this website is intended only to aid you in making informed decisions about your health. It is not intended to be a substitute for advice and treatment

prescribed by a registered dietitian, nutritionist or doctor. The content of this website may not be used as a basis or means for any form of self-diagnosis. If you suspect

that youhave a medical problem, we urge you to seek the help of a medical practitioner.


* These statements have not been approved by the FDA.  This product is not intended to diagnose, treat, cure, or prevent any disease.

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